Replacing the ACM should not affect fuel control at all as far as I know.
I have been wrong before though.
Although if you are talking about the ECM as Halfcrazy suggests, then yes, you would have to remap for that.
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"05 Kingpin Deluxe,100 inch kit with 11:1 pistons,stage III cams, 2-1 RPW pipe,S&S airbox,PC III,Lloyd's rev extended ECU.
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