Replacing the ACM should not affect fuel control at all as far as I know.
I have been wrong before though.
Although if you are talking about the ECM as Halfcrazy suggests, then yes, you would have to remap for that.
'11 Cross Roads
"05 Kingpin Deluxe,100 inch kit with 11:1 pistons,stage III cams, 2-1 RPW pipe,S&S airbox,PC III,Lloyd's rev extended ECU.